Recombinant Human Sodium-dependent neutral amino acid transporter B (0)AT2 (SLC6A15), Truncated

Uniprot Id

Q9H2J7

Target Species

Human

Target Name

SLC6A15

Target Full Name

Sodium-dependent neutral amino acid transporter B(0)AT2

Target Function

Functions as a sodium-dependent neutral amino acid transporter. Exhibits preference for the branched-chain amino acids, particularly leucine, valine and isoleucine and methionine. Mediates the saturable, pH-sensitive and electrogenic cotransport of proline and sodium ions with a stoichiometry of 1:1. May have a role as transporter for neurotransmitter precursors into neurons. In contrast to other members of the neurotransmitter transporter family, does not appear to be chloride-dependent.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family, SLC6A15 subfamily

Target Tissue Specificity

Almost exclusively expressed in the brain.

Target Synonyms

hv7 3; MGC87066; NTT73; Orphan sodium and chloride dependent neurotransmitter transporter NTT73; Orphan transporter v7 3; S6A15_HUMAN; SBAT1; SLC6A15; sodium- and chloride-dependent neurotransmitter transporter NTT73; Sodium-coupled branched-chain amino-acid transporter 1; Sodium-dependent neutral amino acid transporter B(0)AT2; Solute carrier family 6 (neutral amino acid transporter) member 15; Solute carrier family 6 member 15; Transporter v7-3; V7 3

Target Background

This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene.