Recombinant Human Sodium/glucose cotransporter 1 (SLC5A1), Truncated

Uniprot Id

P13866

Target Species

Human

Target Name

SLC5A1

Target Full Name

Sodium/glucose cotransporter 1

Target Function

Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

Target Involvement

Congenital glucose/galactose malabsorption (GGM)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Sodium:solute symporter (SSF) (TC 2.A.21) family

Target Tissue Specificity

Expressed mainly in intestine and kidney.

Target Synonyms

D22S675; High affinity sodium glucose cotransporter 1; High affinity sodium glucose cotransporter; High affinity sodium-glucose cotransporter; Human Na+/glucose cotransporter 1; Na(+)/glucose cotransporter 1; Na+/glucose cotransporter 1; NAGT; SC5A1_HUMAN; SGLT 1; SGLT1; SLC5A1; Sodium glucose cotransporter 1; Sodium/glucose cotransporter 1; Solute carrier family 5 (sodium/glucose cotransporter) member 1; Solute carrier family 5 member 1

Target Background

This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene.