Recombinant Human Solute carrier organic anion transporter family member 4C1 (SLCO4C1), Truncated

Uniprot Id

Q6ZQN7

Target Species

Human

Target Name

SLCO4C1

Target Full Name

Solute carrier organic anion transporter family member 4C1

Target Function

Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surface proteins to facilitate the acquisition of the ability to fertilize the egg

Target Subcellular Location

Basolateral cell membrane; Multi-pass membrane protein.

Target Protein Families

Organo anion transporter (TC 2.A.60) family

Target Tissue Specificity

Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.

Target Synonyms

SLCO4C1; OATP4C1; OATPX; SLC21A20Solute carrier organic anion transporter family member 4C1; OATP-H; Organic anion transporter M1; OATP-M1; Solute carrier family 21 member 20