Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
| Cat.No | ACP10043 | Target Name | SPATA2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-520 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9UM82 |
|---|
Uniprot Id
Q9UM82
Target Species
Human
Target Name
SPATA2
Target Full Name
Spermatogenesis-associated protein 2
Target Function
Bridging factor that mediates the recruitment of CYLD to the LUBAC complex, thereby regulating TNF-alpha-induced necroptosis. Acts as a direct binding intermediate that bridges RNF31/HOIP, the catalytic subunit of the LUBAC complex, and the deubiquitinase (CYLD), thereby recruiting CYLD to the TNF-R1 signaling complex (TNF-RSC). Required to activate the 'Met-1'- (linear) and 'Lys-63'-linked deubiquitinase activities of CYLD. Controls the kinase activity of RIPK1 and TNF-alpha-induced necroptosis by promoting 'Met-1'-linked deubiquitination of RIPK1 by CYLD.
Target Subcellular Location
Cytoplasm. Nucleus.
Target Protein Families
SPATA2 family
Target Tissue Specificity
Present at high level in Sertoli cells, but not detected in spermatogenic cells (at protein level). Low expression in spleen, thymus and prostate.
Target Synonyms
FLJ13167; KIAA0757; PD 1; PD1; PPP1R145; Protein phosphatase 1 regulatory subunit 145; SPAT2_HUMAN; SPATA 2; SPATA2; Spermatogenesis associated 2; Spermatogenesis associated PD1; Spermatogenesis associated protein 2; Spermatogenesis associated protein PD1; Spermatogenesis-associated protein 2; Spermatogenesis-associated protein PD1; Tamo
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
