Recombinant Human Spermatogenesis-defective protein 39 homolog (SPE39)

Cat.No	ACP02808	Target Name	VIPAS39
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	1-493aa	Mol Weight	73.0kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP02808

Target Name

VIPAS39

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-493aa

Mol Weight

73.0kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9H9C1

Background Information

Uniprot Id

Q9H9C1
Target Species

Human
Target Name

VIPAS39
Target Full Name

Spermatogenesis-defective protein 39 homolog
Target Function

Proposed to be involved in endosomal maturation implicating in part VPS33B. In epithelial cells, the VPS33B:VIPAS39 complex may play a role in the apical RAB11A-dependent recycling pathway and in the maintenance of the apical-basolateral polarity. May play a role in lysosomal trafficking, probably via association with the core HOPS complex in a discrete population of endosomes; the functions seems to be independent of VPS33B. May play a role in vesicular trafficking during spermatogenesis. May be involved in direct or indirect transcriptional regulation of E-cadherin.
Target Involvement

Arthrogryposis, renal dysfunction and cholestasis syndrome 2 (ARCS2)
Target Subcellular Location

Cytoplasm. Cytoplasmic vesicle. Early endosome. Recycling endosome. Late endosome. Note=Colocalizes in clusters with VPS33B at cytoplasmic organelles (PubMed:19109425).
Target Protein Families

SPE39 family
Target Research Area

Others
Target Synonyms

Apical basolateral polarity regulator; FLJ12707; hSPE-39; Protein spe-39 homolog; SPE 39; SPE 39 protein; SPE39; Uncharacterized protein C14orf133; vipar; VIPAR_HUMAN; VPS16B; VPS33B interacting protein; VPS33B interacting protein apical basolateral polarity regulator; VPS33B interacting protein involved in polarity and apical protein restriction; VPS33B-interacting protein
Target Background

Involved in endosome to lysosome transport and intracellular protein transport. Acts upstream of or within collagen metabolic process and peptidyl-lysine hydroxylation. Located in Golgi apparatus and endosome. Implicated in arthrogryposis, renal dysfunction, and cholestasis 2.

Recombinant Human Spermatogenesis-defective protein 39 homolog (SPE39)

Specifications

Immunogen Information

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