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A DNA sequence encoding the full-length human Steroid 21-hydroxylase (CYP21A2) protein was fused with a 6xHis tag at the N-terminus and then expressed in the yeast. The forming protein is the Recombinant Human CYP21A2 protein, which contains 494 amino acids. Its purity was measure by SDS-PAGE and reached up to 90%. This in-stock recombinant CYP21A2 protein is not only used for antibody synthesis but also in the studies of signal transduction. CYP21A2, a member of the microsomal cytochrome P450 family, is a critical enzyme of the glucocorticoid and mineralocorticoid biosynthesis in the adrenal cortex. Mutations in the CYP21A2 gene lead to abrupt truncations of the protein per se and further severely damage enzymatic activity, resulting in salt-wasting (SW) congenital adrenal hyperplasia (CAH).
A DNA sequence encoding the full-length human Steroid 21-hydroxylase (CYP21A2) protein was fused with a 6xHis tag at the N-terminus and then expressed in the yeast. The forming protein is the Recombinant Human CYP21A2 protein, which contains 494 amino acids. Its purity was measure by SDS-PAGE and reached up to 90%. This in-stock recombinant CYP21A2 protein is not only used for antibody synthesis but also in the studies of signal transduction.
CYP21A2, a member of the microsomal cytochrome P450 family, is a critical enzyme of the glucocorticoid and mineralocorticoid biosynthesis in the adrenal cortex. Mutations in the CYP21A2 gene lead to abrupt truncations of the protein per se and further severely damage enzymatic activity, resulting in salt-wasting (SW) congenital adrenal hyperplasia (CAH).
| Cat.No | ACP02564 | Target Name | CYP21A2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Yeast |
| Expression Range | 1-495aa | Mol Weight | 57.9kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P08686 |
|---|
Uniprot Id
P08686
Target Species
Human
Target Name
CYP21A2
Target Full Name
Steroid 21-hydroxylase
Target Function
A cytochrome P450 monooxygenase that plays a major role in adrenal steroidogenesis. Catalyzes the hydroxylation at C-21 of progesterone and 17alpha-hydroxyprogesterone to respectively form 11-deoxycorticosterone and 11-deoxycortisol, intermediate metabolites in the biosynthetic pathway of mineralocorticoids and glucocorticoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
Target Involvement
Adrenal hyperplasia 3 (AH3)
Target Subcellular Location
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Target Protein Families
Cytochrome P450 family
Target Research Area
Signal Transduction
Target Synonyms
CYP21; 21 OHase; 21-OHase; CA21H ; CAH1; CP21A_HUMAN; CPS1; CYP21A 2; CYP21A2; CYP21B; Cytochrome P-450c21; Cytochrome P450 21; Cytochrome P450 C21B; Cytochrome P450 XXI; Cytochrome P450; family 21; subfamily A; polypeptide 2; Cytochrome P450; subfamily XXIA (steroid 21 hydroxylase; congenital adrenal hyperplasia); polypeptide 2; Cytochrome P450-C21; Cytochrome P450-C21B; P450 C21; P450 C21B; P450c21B; Steroid 21 hydroxylase; Steroid 21 monooxygenase; Steroid 21-hydroxylase
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