Recombinant Human Storkhead-box protein 1 (STOX1), Truncated

Uniprot Id

Q6ZVD7

Target Species

Human

Target Name

STOX1

Target Full Name

Storkhead-box protein 1

Target Function

Involved in regulating the levels of reactive oxidative species and reactive nitrogen species and in mitochondrial homeostasis in the placenta. Required for regulation of inner ear epithelial cell proliferation via the AKT signaling pathway.; Involved in cell cycle regulation by binding to the CCNB1 promoter, up-regulating its expression and promoting mitotic entry. Induces phosphorylation of MAPT/tau.

Target Involvement

Pre-eclampsia/eclampsia 4 (PEE4)

Target Subcellular Location

[Isoform A]: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform B]: Nucleus.; [Isoform C]: Nucleus, nucleolus.

Target Tissue Specificity

Expressed in placenta, including the invasive extravillus trophoblast cells.

Target Synonyms

STOX1; C10orf24; Storkhead-box protein 1; Winged-helix domain-containing protein

Target Background

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of G2/M transition of mitotic cell cycle; positive regulation of protein phosphorylation; and regulation of gene expression. Located in centrosome; cytosol; and nuclear lumen. Implicated in pre-eclampsia. Biomarker of Alzheimer's disease.