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The production of this Recombinant Human SDHA protein required the insertion of a DNA fragment (SDHA, 44-293aa) into an expression vector and the transferral of this vector into E.coli cells (the step of transformation). The cells were then cultured and induced to express the SDHA protein. This recombinant protein was fused with N-terminal GST tag. Its purity is 90%+ determined by SDS-PAGE.SDHA(also called SDH2 or SDHF) is a gene encoding a protein called succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA) in human. SDHA is also known as flavoprotein subunit of complex II or Fp and belongs to FAD-dependent oxidoreductase 2 family. The protein encoded by SDHA gene is a major catalytic subunit of succinate-ubiquinone oxidoreductase, which is a complex involved in the mitochondrial respiratory chain. In humans, missense mutations in the SDHA gene are associated with severe diseasees, such as Leigh syndrome and paraganglioma tumors.
The production of this Recombinant Human SDHA protein required the insertion of a DNA fragment (SDHA, 44-293aa) into an expression vector and the transferral of this vector into E.coli cells (the step of transformation). The cells were then cultured and induced to express the SDHA protein. This recombinant protein was fused with N-terminal GST tag. Its purity is 90%+ determined by SDS-PAGE.SDHA(also called SDH2 or SDHF) is a gene encoding a protein called succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SDHA) in human. SDHA is also known as flavoprotein subunit of complex II or Fp and belongs to FAD-dependent oxidoreductase 2 family. The protein encoded by SDHA gene is a major catalytic subunit of succinate-ubiquinone oxidoreductase, which is a complex involved in the mitochondrial respiratory chain. In humans, missense mutations in the SDHA gene are associated with severe diseasees, such as Leigh syndrome and paraganglioma tumors.
| Cat.No | ACP08777 | Target Name | SDHA |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 44-293aa | Mol Weight | 54.1kDa |
| Protein Length | Partial | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P31040 |
|---|
Uniprot Id
P31040
Target Species
Human
Target Name
SDHA
Target Full Name
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Target Function
Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). Can act as a tumor suppressor.
Target Involvement
Mitochondrial complex II deficiency (MT-C2D); Leigh syndrome (LS); Cardiomyopathy, dilated 1GG (CMD1GG); Paragangliomas 5 (PGL5)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families
FAD-dependent oxidoreductase 2 family, FRD/SDH subfamily
Target Research Area
Transport
Target Synonyms
CMD1GG; DHSA_HUMAN; Flavoprotein subunit of complex II; Fp; PGL5; SDH 2; SDH1; SDH2; SDHA; SDHF; Succinate dehydrogenase [ubiquinone] flavoprotein subunit; Succinate dehydrogenase [ubiquinone] flavoprotein subunit mitochondrial; Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Succinate dehydrogenase complex flavoprotein subunit A; Succinate dehydrogenase complex flavoprotein subunit; Succinate dehydrogenase complex flavoprotein subunit precursor; Succinate dehydrogenase complex subunit A; Succinate dehydrogenase complex subunit A flavoprotein (Fp); Succinate dehydrogenase complex subunit A flavoprotein
Target Background
This gene encodes a major catalytic subunit of succinate-ubiquinone oxidoreductase, a complex of the mitochondrial respiratory chain. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. Mutations in this gene have been associated with a form of mitochondrial respiratory chain deficiency known as Leigh Syndrome. A pseudogene has been identified on chromosome 3q29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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