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Recombinant Human Sulfotransferase 1A3 (SULT1A3)

ACP02686

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP02686 Target NameSULT1A3
FormLiquid or Lyophilized powderExpression SystemE.coli
Expression Range1-295aaMol Weight61.2kDa
Protein LengthFull lengthPurityGreater than 90% as determined by SDS-PAGE.
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDP0DMM9
Background Information
  • Uniprot Id

    P0DMM9

  • Target Species

    Human

  • Target Name

    SULT1A3

  • Target Full Name

    Sulfotransferase 1A3

  • Target Function

    Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic monoamines (neurotransmitters such as dopamine, norepinephrine and serotonin) and phenolic and catechol drugs.

  • Target Subcellular Location

    Cytoplasm.

  • Target Protein Families

    Sulfotransferase 1 family

  • Target Tissue Specificity

    Liver, colon, kidney, lung, brain, spleen, small intestine, placenta and leukocyte.

  • Target Research Area

    Neuroscience

  • Target Synonyms

    SULT1A3; STM; Sulfotransferase 1A3; ST1A3; EC 2.8.2.1; Aryl sulfotransferase 1A3/1A4; Catecholamine-sulfating phenol sulfotransferase; HAST3; M-PST; Monoamine-sulfating phenol sulfotransferase; Placental estrogen sulfotransferase; Sulfotransferase 1A3/1A4; Sulfotransferase; monoamine-preferring; Thermolabile phenol sulfotransferase; TL-PST

  • Target Background

    Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes a phenol sulfotransferase with thermolabile enzyme activity. Four sulfotransferase genes are located on the p arm of chromosome 16; this gene and SULT1A4 arose from a segmental duplication. This gene is the most centromeric of the four sulfotransferase genes. Read-through transcription exists between this gene and the upstream SLX1A (SLX1 structure-specific endonuclease subunit homolog A) gene that encodes a protein containing GIY-YIG domains.

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