Recombinant Human Synaptotagmin-like protein 2 (SYTL2), Truncated

Uniprot Id

Q9HCH5

Target Species

Human

Target Name

SYTL2

Target Full Name

Synaptotagmin-like protein 2

Target Function

Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive.

Target Subcellular Location

[Isoform 1]: Cytoplasm. Cell membrane.; [Isoform 4]: Cell membrane.

Target Tissue Specificity

Isoform 1 is expressed in hematopoietic lineages with a strong expression in CD4 and CD8 T-lymphocytes. It is also widely expressed in nonhematopoietic tissues. Isoform 5 is expressed only in nonhematopoietic tissues. Isoform 4 is expressed in pancreatic

Target Synonyms

Breast cancer-associated antigen SGA-72M; CHR11SYT; EXO4; Exophilin-4; FLJ20163; FLJ21219; KIAA1597; MGC102768; SGA72M; SLP2; SLP2A; Synaptotagmin-like protein 2; SYTL2; SYTL2_HUMAN

Target Background

The protein encoded by this gene is a synaptotagmin-like protein (SLP) that belongs to a C2 domain-containing protein family. The SLP homology domain (SHD) of this protein has been shown to specifically bind the GTP-bound form of Ras-related protein Rab-27A (RAB27A). This protein plays a role in RAB27A-dependent vesicle trafficking and controls melanosome distribution in the cell periphery. Alternative splicing results in multiple transcript variants encoding distinct isoforms.