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| Cat.No | ACP21136 | Target Name | TTI1 |
|---|---|---|---|
| Target Synonyms | TTI1; KIAA0406; SMG10; TELO2-interacting protein 1 homolog; Protein SMG10 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O43156 |
|---|
Uniprot Id
O43156
Target Species
Human
Target Name
TTI1
Target Full Name
TELO2-interacting protein 1 homolog
Target Function
Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals.
Target Subcellular Location
Cytoplasm.
Target Protein Families
Tti1 family
Target Tissue Specificity
Widely expressed.
Target Synonyms
TTI1; KIAA0406; SMG10; TELO2-interacting protein 1 homolog; Protein SMG10
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