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| Cat.No | ACP00631 | Target Name | TENT4A |
|---|---|---|---|
| Target Synonyms | DNA polymerase sigma;LAK-1;Non-canonical poly(A) RNA polymerase PAPD7 ;PAP-associated domain-containing protein 7;TRAMP-like complex polyadenylate polymerase | Form | Liquid or Lyophilized powder |
| Expression System | in vitro E.coli expression system | Expression Range | 1-542aa |
| Mol Weight | 72.8 kDa | Protein Length | Partial of Isoform 2 |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q5XG87 |
|---|
Uniprot Id
Q5XG87
Target Species
Human
Target Name
TENT4A
Target Full Name
Terminal nucleotidyltransferase 4A
Target Function
Terminal nucleotidyltransferase that catalyzes preferentially the transfert of ATP and GTP on RNA 3' poly(A) tail creating a heterogeneous 3' poly(A) tail leading to mRNAs stabilization by protecting mRNAs from active deadenylation. Also functions as a catalytic subunit of a TRAMP-like complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism. Polyadenylation with short oligo(A) tails is required for the degradative activity of the exosome on several of its nuclear RNA substrates. Has no terminal uridylyltransferase activity, and does not play a role in replication-dependent histone mRNA degradation via uridylation
Target Subcellular Location
Cytoplasm. Nucleus, nucleoplasm.
Target Protein Families
DNA polymerase type-B-like family
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
DNA polymerase kappa; DNA polymerase sigma; LAK 1; LAK-1; LAK1; OTTHUMP00000115520; PAP associated domain containing 7; PAP-associated domain-containing protein 7; Papd7; PAPD7_HUMAN; POLK; POLS; Polymerase (DNA directed) sigma; Polymerase DNA Directed Sigma; Terminal uridylyltransferase 5; Topoisomerase related function protein 4 1; Topoisomerase-related function protein 4-1; TRF4 1; TRF4; TRF4-1; TRF41; TUTase 5; TUTASE5
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