Recombinant Human Thioredoxin domain-containing protein 5 (TXNDC5)

Uniprot Id

Q8NBS9

Target Species

Human

Target Name

TXNDC5

Target Full Name

Thioredoxin domain-containing protein 5

Target Function

Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast.

Target Subcellular Location

Endoplasmic reticulum lumen.

Target Protein Families

Protein disulfide isomerase family

Target Research Area

Cell Biology

Target Synonyms

EndoPDI; Endoplasmic reticulum protein ERp46; Endoplasmic reticulum resident protein 46; Endothelial protein disulphide isomerase; ER protein 46; ERp46; Hcc 2; MGC3178; PDIA15; Protein disulfide isomerase family A member 15; STRF8; Thioredoxin domain containing 5 (endoplasmic reticulum); Thioredoxin domain containing 5; Thioredoxin domain containing protein 5; Thioredoxin domain-containing protein 5; Thioredoxin like protein p46; Thioredoxin related protein; Thioredoxin-like protein p46; TLP46; TXND5_HUMAN; TXNDC 5; Txndc5

Target Background

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene.