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Amino acids 40-330 form the expressed segment for recombinant Human TMEFF1. This TMEFF1 protein is theoretically predicted to have a molecular weight of 38.5 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 10xHis tag and C-terminal Myc tag into the TMEFF1 encoding gene fragment was conducted, allowing for easier detection and purification of the TMEFF1 protein in subsequent stages.Human tomoregulin-1 (TMEFF1) functions as a transmembrane protein involved in cellular signaling and modulation of cell growth. The primary function of TMEFF1 includes influencing intracellular pathways related to cell proliferation and differentiation. Investigating TMEFF1 provides insights into cellular processes, cancer biology, and neurodevelopmental mechanisms. In cancer research, TMEFF1's aberrant expression is associated with various cancers, making it a potential biomarker and therapeutic target. In neurobiology, TMEFF1 is implicated in neuronal differentiation and development.
Amino acids 40-330 form the expressed segment for recombinant Human TMEFF1. This TMEFF1 protein is theoretically predicted to have a molecular weight of 38.5 kDa. This protein is generated in a e.coli-based system. Fusion of the N-terminal 10xHis tag and C-terminal Myc tag into the TMEFF1 encoding gene fragment was conducted, allowing for easier detection and purification of the TMEFF1 protein in subsequent stages.Human tomoregulin-1 (TMEFF1) functions as a transmembrane protein involved in cellular signaling and modulation of cell growth. The primary function of TMEFF1 includes influencing intracellular pathways related to cell proliferation and differentiation. Investigating TMEFF1 provides insights into cellular processes, cancer biology, and neurodevelopmental mechanisms. In cancer research, TMEFF1’s aberrant expression is associated with various cancers, making it a potential biomarker and therapeutic target. In neurobiology, TMEFF1 is implicated in neuronal differentiation and development.
| Cat.No | ACP02361 | Target Name | TMEFF1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 40-330aa | Mol Weight | 38.5 kDa |
| Protein Length | Partial | Purity | Greater than 85% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IYR6 |
|---|
Uniprot Id
Q8IYR6
Target Species
Human
Target Name
TMEFF1
Target Full Name
Tomoregulin-1
Target Function
May inhibit NODAL and BMP signaling during neural patterning. May be a tumor suppressor in brain cancers.
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Tomoregulin family
Target Tissue Specificity
Expressed predominantly in brain, and at lower levels in heart, placenta and skeletal muscle. Down-regulated in brain tumors as compared to control brain tissues.
Target Research Area
Others
Target Synonyms
C9orf2; C9orf3 TMEFF1; C9orf30 TMEFF1; C9orf30 TMEFF1 fusion protein; Cancer/testis antigen family 120 member 1; CT120.1; H 7365; H7365; MSANTD3-TMEFF1 readthrough; TEFF 1; TEFF1; TEFF1_HUMAN; TMEFF 1; TMEFF1; Tomoregulin-1; Tomoregulin-1 precursor; TR 1; TR-1; TR1; Transmembrane protein with EGF like and two follistatin like domains 1; Transmembrane protein with EGF-like and one follistatin-like domain
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