Recombinant Human Transmembrane and ubiquitin-like domain-containing protein 1 (TMUB1), Truncated

Uniprot Id

Q9BVT8

Target Species

Human

Target Name

TMUB1

Target Full Name

Transmembrane and ubiquitin-like domain-containing protein 1

Target Function

Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR. Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface. Acts as negative regulator of hepatocyte growth during regeneration.; May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation. May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1.

Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane. Recycling endosome. Cytoplasm. Nucleus. Nucleus, nucleolus.; [iHOPS]: Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus. Nucleus.

Target Tissue Specificity

Ubiquitously expressed with highest levels in mammary and thyroid glands, bone marrow and spleen; limited expression in cardiac, pancreatic and ovarian tissues.

Target Synonyms

TMUB1; C7orf21; DULP; HOPS; SB144; UNQ763/PRO1555; Transmembrane and ubiquitin-like domain-containing protein 1; Dendritic cell-derived ubiquitin-like protein; Hepatocyte odd protein shuttling protein; Ubiquitin-like protein SB144