Recombinant Human Trem-like transcript 1 protein (TREML1), Truncated

Uniprot Id

Q86YW5

Target Species

Human

Target Name

TREML1

Target Full Name

Trem-like transcript 1 protein

Target Function

Cell surface receptor that may play a role in the innate and adaptive immune response.

Target Subcellular Location

Cell membrane; Single-pass type I membrane protein. Cytoplasm. Note=Sequestered in cytoplasmic vesicles in resting platelets (PubMed:15100151). Transported to the cell surface after stimulation by thrombin (PubMed:15100151). Soluble fragments can be released into the serum by proteolysis (PubMed:16505478).

Target Tissue Specificity

Detected in platelets, monocytic leukemia and in T-cell leukemia.

Target Synonyms

dJ238O23.3; GLTL1825; MGC119173; PRO3438; TLT 1; TLT-1; TLT1; TREM like transcript 1; Trem like transcript 1 protein; Trem-like transcript 1 protein; TREML 1; Treml1; Triggering receptor expressed on myeloid cells like 1; Triggering receptor expressed on myeloid cells like protein 1; Triggering receptor expressed on myeloid cells-like protein 1; TRML1_HUMAN

Target Background

This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants