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Recombinant Human Tripartite motif-containing protein 14 (TRIM14)

ACP18373

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Specifications

Cat.No	ACP18373	Target Name	TRIM14
Target Synonyms	5830400N10Rik ; KIAA0129; pub; TRI14_HUMAN; TRIM14; tripartite motif protein 14; tripartite motif protein TRIM14; tripartite motif-containing 14; Tripartite motif-containing protein 14	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-442
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q14142

Background Information

Uniprot Id

Q14142
Target Species

Human
Target Name

TRIM14
Target Full Name

Tripartite motif-containing protein 14
Target Function

Plays an essential role in the innate immune defense against viruses and bacteria. Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways. Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation. Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression. Inhibits the transcriptional activity of SPI1 in a dose-dependent manner.
Target Subcellular Location

Mitochondrion outer membrane. Cytoplasmic vesicle, phagosome.
Target Protein Families

TRIM/RBCC family
Target Tissue Specificity

Highest expression in liver; undetectable in skeletal muscle.
Target Synonyms

5830400N10Rik ; KIAA0129; pub; TRI14_HUMAN; TRIM14; tripartite motif protein 14; tripartite motif protein TRIM14; tripartite motif-containing 14; Tripartite motif-containing protein 14

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Recombinant Human Tripartite motif-containing protein 14 (TRIM14)

Specifications

Immunogen Information

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