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| Cat.No | ACP17574 | Target Name | TRMT5 |
|---|---|---|---|
| Target Synonyms | TRMT5; KIAA1393; TRM5; tRNA; guanine(37)-N1)-methyltransferase; EC 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homolog | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-509 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q32P41 |
|---|
Uniprot Id
Q32P41
Target Species
Human
Target Name
TRMT5
Target Full Name
tRNA (guanine(37)-N(1))-methyltransferase
Target Function
Involved in mitochondrial tRNA methylation. Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.
Target Involvement
Combined oxidative phosphorylation deficiency 26 (COXPD26)
Target Subcellular Location
Mitochondrion matrix. Nucleus. Cytoplasm.
Target Protein Families
Class I-like SAM-binding methyltransferase superfamily, TRM5/TYW2 family
Target Synonyms
TRMT5; KIAA1393; TRM5; tRNA; guanine(37)-N1)-methyltransferase; EC 2.1.1.228; M1G-methyltransferase; tRNA [GM37] methyltransferase; tRNA methyltransferase 5 homolog
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