Recombinant Human tRNA-splicing endonuclease subunit Sen34 (TSEN34)

Uniprot Id

Q9BSV6

Target Species

Human

Target Name

TSEN34

Target Full Name

tRNA-splicing endonuclease subunit Sen34

Target Function

Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events

Target Involvement

Pontocerebellar hypoplasia 2C (PCH2C)

Target Subcellular Location

Nucleus. Nucleus, nucleolus. Note=May be transiently localized in the nucleolus.

Target Protein Families

TRNA-intron endonuclease family

Target Synonyms

HsSen34; LENG 5; LENG5; Leukocyte receptor cluster (LRC) member 5; Leukocyte receptor cluster member 5; SEN 34; SEN34; SEN34_HUMAN; SEN34L; tRNA intron endonuclease Sen34; tRNA splicing endonuclease 34 homolog; tRNA splicing endonuclease subunit 34; tRNA splicing endonuclease subunit Sen34; tRNA-intron endonuclease Sen34; tRNA-splicing endonuclease subunit Sen34; TSEN 34; Tsen34