Recombinant Human Tryptophan–tRNA ligase, mitochondrial (WARS2)

Uniprot Id

Q9UGM6

Target Species

Human

Target Name

WARS2

Target Full Name

Tryptophan--tRNA ligase, mitochondrial

Target Function

Mitochondrial aminoacyl-tRNA synthetase that activate and transfer the amino acids to their corresponding tRNAs during the translation of mitochondrial genes and protein synthesis.

Target Involvement

Neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures (NEMMLAS)

Target Subcellular Location

Mitochondrion matrix.

Target Protein Families

Class-I aminoacyl-tRNA synthetase family

Target Tissue Specificity

Brain.

Target Synonyms

WARS2; Tryptophan--tRNA ligase; mitochondrial; EC 6.1.1.2;; Mt)TrpRS; Tryptophanyl-tRNA synthetase; TrpRS

Target Background

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Two forms of tryptophanyl-tRNA synthetase exist, a cytoplasmic form, named WARS, and a mitochondrial form, named WARS2. This gene encodes the mitochondrial tryptophanyl-tRNA synthetase. Two alternative transcripts encoding different isoforms have been described.