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Recombinant Human Tubulin alpha-4A chain (TUBA4A)

ACP24676

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP24676 Target NameTUBA4A
Target Synonymsalpha, alpha 1, alpha 1 (testis specific); tubulin, alpha 4a; Tubulin, like; Tubulin, testis-specific; TubulinFormLyophilized powder
Expression SystemCustom Production. Please inquire and provide the desire expression system.Expression Range1-448
Protein LengthFull length proteinPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDP68366
Background Information
  • Uniprot Id

    P68366

  • Target Species

    Human

  • Target Name

    TUBA4A

  • Target Full Name

    Tubulin alpha-4A chain

  • Target Function

    Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

  • Target Involvement

    Amyotrophic lateral sclerosis 22, with or without frontotemporal dementia (ALS22)

  • Target Subcellular Location

    Cytoplasm, cytoskeleton.

  • Target Protein Families

    Tubulin family

  • Target Synonyms

    Alpha-tubulin 1; ALS22; B ALPHA 1; bA408E5.3; H2 ALPHA; Hum a tub1; Hum a tub2; LIS3; MGC171407; MGC55332; TBA4A_HUMAN; Testis-specific alpha-tubulin; TUBA1; TUBA1A; tuba1l; Tuba4a; Tubulin alpha 1 chain; Tubulin alpha; Tubulin alpha-1 chain; tubulin alpha-1B chain; Tubulin alpha-4A chain; Tubulin H2-alpha; Tubulin, alpha 1 (testis specific); tubulin, alpha 1, like; Tubulin, alpha 4a; Tubulin, alpha, testis-specific; Tubulin, alpha-1

  • Target Background

    Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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