Recombinant Human Tubulin gamma-1 chain (TUBG1)

Uniprot Id

P23258

Target Species

Human

Target Name

TUBG1

Target Full Name

Tubulin gamma-1 chain

Target Function

Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.

Target Involvement

Cortical dysplasia, complex, with other brain malformations 4 (CDCBM4)

Target Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle.

Target Protein Families

Tubulin family

Target Synonyms

Gamma-1-tubulin; Gamma-tubulin complex component 1; GCP-1; TBG1_HUMAN; TUBG; TUBG1; TUBGCP1; Tubulin gamma-1 chain; Tubulin, gamma 1; Tubulin, gamma polypeptide

Target Background

This gene encodes a member of the tubulin superfamily. The encoded protein localizes to the centrosome where it binds to microtubules as part of a complex referred to as the gamma-tubulin ring complex. The protein mediates microtubule nucleation and is required for microtubule formation and progression of the cell cycle. A pseudogene of this gene is found on chromosome 7.