Recombinant Human Tubulinyl-Tyr carboxypeptidase 1 (VASH1)

The region for expressing recombinant Human VASH1 contains amino acids 1-204. The theoretical molecular weight of the VASH1 protein is 27.3 kDa. This VASH1 protein is produced using e.coli expression system. Fusion of the N-terminal 6xHis tag into the VASH1 encoding gene fragment was conducted, allowing for easier detection and purification of the VASH1 protein in subsequent stages.Human tubulinyl-Tyr carboxypeptidase 1 (VASH1) is a protein involved in angiogenesis and microtubule dynamics. VASH1 mainly functions to regulate microtubule assembly and disassembly, impacting cellular processes like cell migration and division. Investigating VASH1 provides insights into microtubule regulation, angiogenesis, and cellular processes, offering potential applications in cancer therapy, vascular disorders, and neurobiology. In vascular biology, VASH1 influences angiogenesis by modulating endothelial cell behavior. In cancer research, VASH1's role in angiogenesis makes it relevant for tumor growth and metastasis studies, with potential applications in anti-angiogenic therapies. Additionally, VASH1 is implicated in neuronal development.

ACP03976

The region for expressing recombinant Human VASH1 contains amino acids 1-204. The theoretical molecular weight of the VASH1 protein is 27.3 kDa. This VASH1 protein is produced using e.coli expression system. Fusion of the N-terminal 6xHis tag into the VASH1 encoding gene fragment was conducted, allowing for easier detection and purification of the VASH1 protein in subsequent stages.Human tubulinyl-Tyr carboxypeptidase 1 (VASH1) is a protein involved in angiogenesis and microtubule dynamics. VASH1 mainly functions to regulate microtubule assembly and disassembly, impacting cellular processes like cell migration and division. Investigating VASH1 provides insights into microtubule regulation, angiogenesis, and cellular processes, offering potential applications in cancer therapy, vascular disorders, and neurobiology. In vascular biology, VASH1 influences angiogenesis by modulating endothelial cell behavior. In cancer research, VASH1’s role in angiogenesis makes it relevant for tumor growth and metastasis studies, with potential applications in anti-angiogenic therapies. Additionally, VASH1 is implicated in neuronal development.

Number

Cat.No	ACP03976	Target Name	VASH1
Target Synonyms	KIAA1036; VASH; VASH1; VASH1_HUMAN; Vasohibin 1; Vasohibin-1	Form	Liquid or Lyophilized powder
Expression System	E.coli	Expression Range	1-204aa
Mol Weight	27.3 kDa	Protein Length	Full Length of Isoform 2
Purity	Greater than 85% as determined by SDS-PAGE.	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP03976

Target Name

VASH1

Target Synonyms

KIAA1036; VASH; VASH1; VASH1_HUMAN; Vasohibin 1; Vasohibin-1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

1-204aa

Mol Weight

27.3 kDa

Protein Length

Full Length of Isoform 2

Purity

Greater than 85% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q7L8A9

Background Information

Uniprot Id

Q7L8A9
Target Species

Human
Target Name

VASH1
Target Full Name

Tubulinyl-Tyr carboxypeptidase 1
Target Function

Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function. Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning. Acts as an angiogenesis inhibitor: inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. This inhibitory effect is selective to endothelial cells as it does not affect the migration of smooth muscle cells or fibroblasts.
Target Subcellular Location

Cytoplasm. Secreted.
Target Protein Families

Vasohibin family
Target Tissue Specificity

Preferentially expressed in endothelial cells. Highly expressed in fetal organs. Expressed in brain and placenta, and at lower level in heart and kidney. Highly detected in microvessels endothelial cells of atherosclerotic lesions.
Target Research Area

Cardiovascular
Target Synonyms

KIAA1036; VASH; VASH1; VASH1_HUMAN; Vasohibin 1; Vasohibin-1
Target Background

Enables actin binding activity and metallocarboxypeptidase activity. Involved in negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell migration; and proteolysis. Acts upstream of or within several processes, including negative regulation of endothelial cell migration; negative regulation of endothelial cell proliferation; and negative regulation of lymphangiogenesis. Located in apical part of cell; endoplasmic reticulum; and extracellular space. Implicated in liver cirrhosis and portal hypertension. Biomarker of liver cirrhosis.

Recombinant Human Tubulinyl-Tyr carboxypeptidase 1 (VASH1)

Specifications

Immunogen Information

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