Recombinant Human U6 snRNA-associated Sm-like protein LSm3 (LSM3)

Uniprot Id

P62310

Target Species

Human

Target Name

LSM3

Target Full Name

U6 snRNA-associated Sm-like protein LSm3

Target Function

Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.

Target Subcellular Location

Nucleus.

Target Protein Families

SnRNP Sm proteins family

Target Synonyms

lsm3; LSM3 homolog; LSM3 protein; LSM3_HUMAN; MDS017; SMX4; U6 small nuclear RNA associated (S. cerevisiae); U6 snRNA associated Sm like protein LSm3; U6 snRNA-associated Sm-like protein LSm3; USS2; YLR438C

Target Background

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.