Recombinant Human Ubiquitin-conjugating enzyme E2 J2 (UBE2J2), Truncated

Uniprot Id

Q8N2K1

Target Species

Human

Target Name

UBE2J2

Target Full Name

Ubiquitin-conjugating enzyme E2 J2

Target Function

Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD).

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type IV membrane protein.

Target Protein Families

Ubiquitin-conjugating enzyme family

Target Synonyms

NCUBE-2; NCUBE2; Non-canonical ubiquitin-conjugating enzyme 2; PRO2121; UB2J2_HUMAN; UBC6; UBC6 homolog; ube2j2; Ubiquitin conjugating enzyme 6; Ubiquitin-conjugating enzyme E2 J2; Yeast UBC6 homolog

Target Background

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.