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| Cat.No | ACP15434 | Target Name | ARPIN |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-226 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q7Z6K5 |
|---|
Uniprot Id
Q7Z6K5
Target Species
Human
Target Name
ARPIN
Target Full Name
Arpin
Target Function
Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competetive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inhibits the ARP2/2 complex in response to Rac signaling and where Rac also stimulates actin polymerization through the WAVE complex. Involved in steering cell migration by controlling its directional persistence.
Target Subcellular Location
Cell projection, lamellipodium.
Target Protein Families
Arpin family
Target Synonyms
2610034B18Rik; Actin related protein 2/3 complex inhibitor; Arp2/3 inhibition protein; ARPIN; C15orf38; Chromosome 15 open reading frame 38 ; CO038_HUMAN; Hypothetical protein LOC348110; MGC61550; RIKEN cDNA 2610034B18; UPF0552 protein C15orf38
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