Recombinant Human Vitamin D-binding protein (GC)

Uniprot Id

P02774

Target Species

Human

Target Name

GC

Target Full Name

Vitamin D-binding protein

Target Function

Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.

Target Subcellular Location

Secreted.

Target Protein Families

ALB/AFP/VDB family

Target Tissue Specificity

Expressed in the liver. Found in plasma, ascites, cerebrospinal fluid and urine.

Target Research Area

Signal Transduction, Transport

Target Synonyms

DBP; DBP/GC; GC; Gc globulin; Gc-globulin; GRD3; Group specific component; Group specific component vitamin D binding protein; Group-specific component; hDBP; VDB; VDBG; VDBP; Vitamin D binding alpha globulin; Vitamin D-binding protein; VTDB_HUMAN

Target Background

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.