Recombinant Human Vitamin K-dependent protein S (PROS1)

Uniprot Id

P07225

Target Species

Human

Target Name

PROS1

Target Full Name

Vitamin K-dependent protein S

Target Function

Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.

Target Involvement

Thrombophilia due to protein S deficiency, autosomal dominant (THPH5); Thrombophilia due to protein S deficiency, autosomal recessive (THPH6)

Target Subcellular Location

Secreted.

Target Tissue Specificity

Plasma.

Target Synonyms

Preproprotein S; Propiece of latent protein S; PROS 1; PROS; PROS_HUMAN; proS1; Protein S alpha; Protein Sa; PS 21; PS 22; PS 23; PS 24; PS 25; PS 26; PS21; PS22; PS23; PS24; PS25; PS26; PSA; THPH5; THPH6; Vitamin K dependent protein S; Vitamin K-dependent plasma protein S; Vitamin K-dependent protein S

Target Background

This gene encodes a vitamin K-dependent plasma protein that functions as a cofactor for the anticoagulant protease, activated protein C (APC) to inhibit blood coagulation. It is found in plasma in both a free, functionally active form and also in an inactive form complexed with C4b-binding protein. Mutations in this gene result in autosomal dominant hereditary thrombophilia. An inactive pseudogene of this locus is located at an adjacent region on chromosome 3. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein.