Recombinant Human Voltage-dependent calcium channel gamma-4 subunit (CACNG4), Truncated

Uniprot Id

Q9UBN1

Target Species

Human

Target Name

CACNG4

Target Full Name

Voltage-dependent calcium channel gamma-4 subunit

Target Function

Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit. Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein.

Target Protein Families

PMP-22/EMP/MP20 family, CACNG subfamily

Target Tissue Specificity

Detected in heart left ventricle.

Target Synonyms

CACNG4; Voltage-dependent calcium channel gamma-4 subunit; Neuronal voltage-gated calcium channel gamma-4 subunit; Transmembrane AMPAR regulatory protein gamma-4; TARP gamma-4

Target Background

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit.