Recombinant Human WAP four-disulfide core domain protein 1 (WFDC1)

Uniprot Id

Q9HC57

Target Species

Human

Target Name

WFDC1

Target Full Name

WAP four-disulfide core domain protein 1

Target Function

Has growth inhibitory activity.

Target Subcellular Location

Secreted.

Target Synonyms

Prostate stromal protein ps20; PS20; ps20 growth inhibitor; WAP four disulfide core domain 1; WAP four disulfide core domain 1 homolog; WAP four-disulfide core domain protein 1; Wfdc1; WFDC1_HUMAN

Target Background

This gene encodes a member of the WAP-type four disulfide core domain family. The WAP-type four-disulfide core domain contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is mapped to chromosome 16q24, an area of frequent loss of heterozygosity in cancers, including prostate, breast and hepatocellular cancers and Wilms' tumor. This gene is downregulated in many cancer types and may be involved in the inhibition of cell proliferation. The encoded protein may also play a role in the susceptibility of certain CD4 memory T cells to human immunodeficiency virus infection. Alternative splicing results in multiple transcript variants.