Recombinant Human WAS/WASL-interacting protein family member 1 (WIPF1)

Uniprot Id

O43516

Target Species

Human

Target Name

WIPF1

Target Full Name

WAS/WASL-interacting protein family member 1

Target Function

Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus.

Target Involvement

Wiskott-Aldrich syndrome 2 (WAS2)

Target Subcellular Location

Cytoplasmic vesicle. Cytoplasm, cytoskeleton. Cell projection, ruffle.

Target Protein Families

Verprolin family

Target Tissue Specificity

Highly expressed in peripheral blood mononuclear cells, spleen, placenta, small intestine, colon and thymus. Lower expression in ovary, heart, brain, lung, liver, skeletal muscle, kidney, pancreas, prostate and testis.

Target Synonyms

WIPF1; WASPIP; WIP; WAS/WASL-interacting protein family member 1; Protein PRPL-2; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein

Target Background

This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene.