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| Cat.No | ACP22680 | Target Name | ZNF445 |
|---|---|---|---|
| Target Synonyms | ZNF445; ZFP445; ZKSCAN15; ZNF168; Zinc finger protein 445; ZFP445; Zinc finger protein 168; Zinc finger protein with KRAB and SCAN domains 15 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P59923 |
|---|
Uniprot Id
P59923
Target Species
Human
Target Name
ZNF445
Target Full Name
Zinc finger protein 445
Target Function
Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZFP57, but seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance.
Target Subcellular Location
Nucleus.
Target Protein Families
Krueppel C2H2-type zinc-finger protein family
Target Synonyms
ZNF445; ZFP445; ZKSCAN15; ZNF168; Zinc finger protein 445; ZFP445; Zinc finger protein 168; Zinc finger protein with KRAB and SCAN domains 15
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