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Recombinant Human Zinc finger protein 57 homolog (ZFP57)

ACP12014

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Specifications

Cat.No	ACP12014	Target Name	ZFP57
Target Synonyms	ZFP57; C6orf40; ZNF698; Zinc finger protein 57 homolog; Zfp-57; Zinc finger protein 698	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-452
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9NU63

Background Information

Uniprot Id

Q9NU63
Target Species

Human
Target Name

ZFP57
Target Full Name

Zinc finger protein 57 homolog
Target Function

Transcription regulator required to maintain maternal and paternal gene imprinting, a process by which gene expression is restricted in a parent of origin-specific manner by epigenetic modification of genomic DNA and chromatin, including DNA methylation. Acts by controlling DNA methylation during the earliest multicellular stages of development at multiple imprinting control regions (ICRs). Acts together with ZNF445, but ZNF445 seems to be the major factor in human early embryonic imprinting maintenance. In contrast, in mice, ZFP57 plays the predominant role in imprinting maintenance. Required for the establishment of maternal methylation imprints at SNRPN locus. Acts as a transcriptional repressor in Schwann cells. Binds to a 5'-TGCCGC-3' consensus sequence and recognizes the methylated CpG within this element.
Target Involvement

Transient neonatal diabetes mellitus 1 (TNDM1)
Target Subcellular Location

Nucleus.
Target Protein Families

Krueppel C2H2-type zinc-finger protein family, ZFP57 subfamily
Target Synonyms

ZFP57; C6orf40; ZNF698; Zinc finger protein 57 homolog; Zfp-57; Zinc finger protein 698

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Recombinant Human Zinc finger protein 57 homolog (ZFP57)

Specifications

Immunogen Information

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