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| Cat.No | ACP21898 | Target Name | ZSWIM8 |
|---|---|---|---|
| Target Synonyms | Zinc finger SWIM domain-containing protein 8; ZSWIM8; ZSWM8_HUMAN | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A7E2V4 |
|---|
Uniprot Id
A7E2V4
Target Species
Human
Target Name
ZSWIM8
Target Full Name
Zinc finger SWIM domain-containing protein 8
Target Function
Substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex that promotes target-directed microRNA degradation (TDMD), a process that mediates degradation of microRNAs (miRNAs). The SCF-like E3 ubiquitin-protein ligase complex acts by catalyzing ubiquitination and subsequent degradation of AGO proteins (AGO1, AGO2, AGO3 and/or AGO4), thereby exposing miRNAs for degradation. Specifically recognizes and binds AGO proteins when they are engaged with a TDMD target. May also acts as a regulator of axon guidance: specifically recognizes misfolded ROBO3 and promotes its ubiquitination and subsequent degradation
Target Subcellular Location
Cytoplasm, cytosol.
Target Synonyms
Zinc finger SWIM domain-containing protein 8; ZSWIM8; ZSWM8_HUMAN
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