Recombinant Human Zinc transporter 4 (SLC30A4), Truncated

Uniprot Id

O14863

Target Species

Human

Target Name

SLC30A4

Target Full Name

Probable proton-coupled zinc antiporter SLC30A4

Target Function

Probably involved in zinc transport out of the cytoplasm, maybe by sequestration into an intracellular compartment.

Target Subcellular Location

Endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein.

Target Protein Families

Cation diffusion facilitator (CDF) transporter (TC 2.A.4) family, SLC30A subfamily

Target Synonyms

SLC30A4; ZNT4; Zinc transporter 4; ZnT-4; Solute carrier family 30 member 4

Target Background

Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]).