Dna Cross-Link Repair 1A Protein (DCLRE1A) Reagents

DNA cross-link repair 1A protein

May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem).

Nucleus. Note=In some cells it may be found in typically 1 or 2 discrete nuclear aggregates of unknown function which also contain TP53BP1. Also found in multiple discrete nuclear foci which increase in number following treatment with ionizing radiation or interstrand cross-linking agents. These foci overlap with those formed by the MRN complex (composed of MRE11, RAD50 and NBN) and BRCA1.

DNA repair metallo-beta-lactamase (DRMBL) family

Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle.

Epigenetics and Nuclear Signaling

Dclre1a; DCR1A_HUMAN; DNA cross link repair 1A; DNA cross link repair gene SNM1; DNA cross-link repair 1A protein; hSNM1; hSNM1A; PSO2; SNM1 homolog A