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The antibody against TPI1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human TPI1 (NP_000356.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
The antibody against TPI1 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human TPI1 (NP_000356.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.
| Cat.No | ADA-11862A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | TPI1 |
| Target Synonyms | TIM; TPI; TPID; HEL-S-49; TPI1 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.05% proclin300, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Mouse kidney, Rat brain, 293T, Mouse brain, Rat skeletal muscle, U-87MG | Application | ELISA, WB, IF/ICC |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-249 of human TPI1 (NP_000356.1). | Target Species | Human |
|---|---|---|---|
| Uniprot ID | P60174 | Immunogen Sequence |
Uniprot Id
P60174
Target Species
Human
Target Name
TPI1
Target Full Name
Triosephosphate isomerase
Target Function
Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis.; It is also responsible for the non-negligible production of methylglyoxal a reactive cytotoxic side-product that modifies and can alter proteins, DNA and lipids.
Target Involvement
Triosephosphate isomerase deficiency (TPID)
Target Subcellular Location
Cytoplasm.
Target Protein Families
Triosephosphate isomerase family
Target Synonyms
TPI1; TPI; Triosephosphate isomerase; TIM; EC 5.3.1.1; Methylglyoxal synthase; EC 4.2.3.3; Triose-phosphate isomerase
Target Background
This gene encodes an enzyme, consisting of two identical proteins, which catalyzes the isomerization of glyceraldehydes 3-phosphate (G3P) and dihydroxy-acetone phosphate (DHAP) in glycolysis and gluconeogenesis. Mutations in this gene are associated with triosephosphate isomerase deficiency. Pseudogenes have been identified on chromosomes 1, 4, 6 and 7. Alternative splicing results in multiple transcript variants.
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