Rabbit anti-Human KDM3A Polyclonal Antibody

Uniprot Id

Q9Y4C1

Target Species

Human

Target Name

KDM3A

Target Full Name

Lysine-specific demethylase 3A

Target Function

Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TNP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.

Target Subcellular Location

Cytoplasm. Nucleus.

Target Protein Families

JHDM2 histone demethylase family

Target Synonyms

DKFZp686A24246; DKFZp686P07111; JHDM2A; JHMD2A; JmjC domain-containing histone demethylation protein 2A; JMJD1; JMJD1A; Jumonji C domain containing histone demethylase 2A; Jumonji domain containing 1; Jumonji domain containing 1A; Jumonji domain containing protein 1A; Jumonji domain-containing protein 1A; Kdm3a; KDM3A_HUMAN; KIAA0742; Lysine (K) specific demethylase 3A; Lysine-specific demethylase 3A; Testis specific protein A; TSGA

Target Background

Enables androgen receptor binding activity; histone H3-methyl-lysine-9 demethylase activity; and iron ion binding activity. Involved in several processes, including androgen receptor signaling pathway; formaldehyde biosynthetic process; and histone H3-K9 demethylation. Located in nucleoplasm. Implicated in cervical cancer and colon cancer. Biomarker of Ewing sarcoma; hepatocellular carcinoma; nasopharynx carcinoma; and prostate cancer.