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The antibody against NDUFS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human NDUFS4 (NP_002486.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
The antibody against NDUFS4 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human NDUFS4 (NP_002486.1) as the immunogen. The polyclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IHC-P, IF/ICC, ELISA.
| Cat.No | ADA-12189A | Clonality | Polyclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | NDUFS4 |
| Target Synonyms | AQDQ; CI-18; MC1DN1; CI-AQDQ; CI-18 kDa; NDUFS4 | Form | Liquid |
| Species Reactivity | Human, Mouse, Rat | Isotype | IgG |
| Storage Buffer | 50% Glycerol, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | Rat brain, 293T, HepG2, MCF7, Mouse bone marrow, Mouse brain, Mouse liver, Rat liver | Application | ELISA, WB, IF/ICC, IHC-P |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human NDUFS4 (NP_002486.1). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MAAVSMSVVLRQTLWRRRAVAVAALSVSRVPTRSLRTSTWRLAQDQTQDTQLITVDEKLDITTLTGVPEEHIKTRKVRIFVPARNNMQSGVNNTKKWKMEFDTRERWENPLMGWASTADPLSNMVLTFSTKEDAVSFAEKNGWSYDIEERKVPKPKSKSYGANFSWNKRTRVSTK | Uniprot ID | O43181 |
Uniprot Id
O43181
Target Species
Human
Target Name
NDUFS4
Target Full Name
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial
Target Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.
Target Involvement
Mitochondrial complex I deficiency (MT-C1D); Leigh syndrome (LS)
Target Subcellular Location
Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Target Protein Families
Complex I NDUFS4 subunit family
Target Synonyms
AQDQ; CI 18; CI 18 kDa; CI AQDQ; CI-18 kDa; CI-AQDQ; Complex I 18 kDa; Complex I AQDQ; Complex I-18 kDa; Complex I-AQDQ; mitochondrial; mitochondrial respiratory chain complex I (18 KD subunit); NADH coenzyme Q reductase; NADH dehydrogenase (ubiquinone) Fe S protein 4 18kDa; NADH dehydrogenase [ubiquinone] iron-sulfur protein 4; NADH dehydrogenase; NADH ubiquinone oxidoreductase 18 kDa subunit; NADH-ubiquinone oxidoreductase 18 kDa subunit; NDUFS4; NDUS4_HUMAN
Target Background
This gene encodes an nuclear-encoded accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I, or NADH:ubiquinone oxidoreductase). Complex I removes electrons from NADH and passes them to the electron acceptor ubiquinone. Mutations in this gene can cause mitochondrial complex I deficiencies such as Leigh syndrome. Alternative splicing results in multiple transcript variants.
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