Rabbit anti-Human DNAJC15 Monoclonal Antibody

The antibody against DNAJC15 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 70-150 of human DNAJC15 (Q9Y5T4) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IF/ICC, ELISA.

ADA-13914A

Number

Cat.No	ADA-13914A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	DNAJC15
Target Synonyms	MCJ; HSD18; DNAJD1; DNAJC15	Form	Liquid
Species Reactivity	Human, Mouse, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	Mouse kidney, Rat brain, 293T, Mouse brain, Mouse testis, Rat testis	Application	ELISA, WB, IF/ICC

Cat.No

ADA-13914A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

DNAJC15

Target Synonyms

MCJ; HSD18; DNAJD1; DNAJC15

Form

Liquid

Species Reactivity

Human, Mouse, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

Mouse kidney, Rat brain, 293T, Mouse brain, Mouse testis, Rat testis

Application

ELISA, WB, IF/ICC

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 70-150 of human DNAJC15 (Q9Y5T4).	Target Species	Human
Immunogen Sequence	ETAKKISTPSFSSYYKGGFEQKMSRREAGLILGVSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH	Uniprot ID	Q9Y5T4

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 70-150 of human DNAJC15 (Q9Y5T4).

Target Species

Human

Immunogen Sequence

ETAKKISTPSFSSYYKGGFEQKMSRREAGLILGVSPSAGKAKIRTAHRRVMILNHPDKGGSPYVAAKINEAKDLLETTTKH

Uniprot ID

Q9Y5T4

Background Information

Uniprot Id

Q9Y5T4
Target Species

Human
Target Name

DNAJC15
Target Full Name

DnaJ homolog subfamily C member 15
Target Function

Negative regulator of the mitochondrial respiratory chain. Prevents mitochondrial hyperpolarization state and restricts mitochondrial generation of ATP. Acts as an import component of the TIM23 translocase complex. Stimulates the ATPase activity of HSPA9.
Target Involvement

Absent or down-regulated in many advanced cases of ovarian adenocarcinoma, due to hypermethylation and allelic loss. Loss of expression correlates with increased resistance to antineoplastic drugs, such as cisplatin.
Target Subcellular Location

Mitochondrion inner membrane; Single-pass membrane protein.
Target Tissue Specificity

Expressed at highest levels in heart, followed by liver and kidney.
Target Synonyms

MCJ; HSD18; DNAJD1; DNAJC15
Target Background

Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor.

Rabbit anti-Human DNAJC15 Monoclonal Antibody

Specifications

Immunogen Information

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