Rabbit anti-Human TC10/RHOQ Monoclonal Antibody

Uniprot Id

P17081

Target Species

Human

Target Name

RHOQ

Target Full Name

Rho-related GTP-binding protein RhoQ

Target Function

Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. May play a role in CFTR trafficking to the plasma membrane. Causes the formation of thin, actin-rich surface projections called filopodia.

Target Subcellular Location

Cytoplasm. Cell membrane; Lipid-anchor.

Target Protein Families

Small GTPase superfamily, Rho family

Target Synonyms

ARHQ; Ras homolog gene family member Q; RAS like family 7 member A; Ras like protein family member 7A ; Ras like protein TC10; Ras related GTP binding protein TC10 ; Ras-like protein family member 7A; Ras-like protein TC10; RASL7A; Rho related GTP binding protein RhoQ; Rho-related GTP-binding protein RhoQ; Rhoq; RHOQ_HUMAN; TC10A

Target Background

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14.