Rabbit anti-Human Chk1 Monoclonal Antibody

Uniprot Id

O14757

Target Species

Human

Target Name

CHEK1

Target Full Name

Serine/threonine-protein kinase Chk1

Target Function

Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence Endogenous repressor of isoform 1, interacts with, and antagonizes CHK1 to promote the S to G2/M phase transition.

Target Subcellular Location

Nucleus. Chromosome. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, NIM1 subfamily

Target Tissue Specificity

Expressed ubiquitously with the most abundant expression in thymus, testis, small intestine and colon.

Target Synonyms

C85740; Cell cycle checkpoint kinase; Checkpoint ; S. pombe; homolog of; 1; Checkpoint kinase 1; Checkpoint kinase 1 homolog (S. pombe); CHEK 1; Chek1; Chk 1; Chk1; CHK1 checkpoint homolog (S. pombe); CHK1_HUMAN; EC 2.7.11.1; rad27; Serine/threonine protein kinase Chk1; Serine/threonine-protein kinase CHK1; STT3; subunit of the oligosaccharyltransferase complex; homolog A (S. cerevisiae)

Target Background

The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene.