Rabbit anti-Human USP25 Monoclonal Antibody

Uniprot Id

Q9UHP3

Target Species

Human

Target Name

USP25

Target Full Name

Ubiquitin carboxyl-terminal hydrolase 25

Target Function

Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.; The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.

Target Subcellular Location

Cytoplasm.; [Isoform USP25m]: Cytoplasm. Nucleus.

Target Protein Families

Peptidase C19 family

Target Tissue Specificity

Isoform USP25a is found in most adult and fetal tissues; expression is moderately high in testis, pancreas, kidney, skeletal muscle, liver, lung, placenta, brain, heart, but very low in peripheral blood, colon, small intestine, ovary, prostate, thymus and

Target Synonyms

Deubiquitinating enzyme 25; Ubiquitin carboxyl-terminal hydrolase 25; Ubiquitin specific peptidase 25; ubiquitin specific protease 25; ubiquitin specific protease USP25; Ubiquitin thiolesterase 25; Ubiquitin-specific-processing protease 25; UBP25_HUMAN; USP on chromosome 21; USP21; USP25

Target Background

Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).