Rabbit anti-Human ABHD5 Monoclonal Antibody

The antibody against ABHD5 was raised in Rabbit using a synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABHD5 (Q8WTS1) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, ELISA.

ADA-16209A

Number

Cat.No	ADA-16209A	Clonality	Monoclonal
Host Species	Rabbit	Target Name	ABHD5
Target Synonyms	CGI58; IECN2; NCIE2; ABHD5	Form	Liquid
Species Reactivity	Human, Rat	Isotype	IgG
Storage Buffer	50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.	Purification Method	Affinity purification
Positive Samples	HepG2, Rat liver, Rat testis, RD	Application	ELISA, WB

Cat.No

ADA-16209A

Clonality

Monoclonal

Host Species

Rabbit

Target Name

ABHD5

Target Synonyms

CGI58; IECN2; NCIE2; ABHD5

Form

Liquid

Species Reactivity

Human, Rat

Isotype

IgG

Storage Buffer

50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3.

Purification Method

Affinity purification

Positive Samples

HepG2, Rat liver, Rat testis, RD

Application

ELISA, WB

Immunogen Description	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABHD5 (Q8WTS1).	Target Species	Human
Immunogen Sequence	TNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPVWIRA	Uniprot ID	Q8WTS1

Immunogen Description

A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABHD5 (Q8WTS1).

Target Species

Human

Immunogen Sequence

TNRPVYAFDLLGFGRSSRPRFDSDAEEVENQFVESIEEWRCALGLDKMILLGHNLGGFLAAAYSLKYPSRVNHLILVEPWGFPERPDLADQDRPIPVWIRA

Uniprot ID

Q8WTS1

Background Information

Uniprot Id

Q8WTS1
Target Species

Human
Target Name

ABHD5
Target Full Name

1-acylglycerol-3-phosphate O-acyltransferase ABHD5
Target Function

Coenzyme A-dependent lysophosphatidic acid acyltransferase that catalyzes the transfert of an acyl group on a lysophosphatidic acid. Functions preferentially with 1-oleoyl-lysophosphatidic acid followed by 1-palmitoyl-lysophosphatidic acid, 1-stearoyl-lysophosphatidic acid and 1-arachidonoyl-lysophosphatidic acid as lipid acceptor. Functions preferentially with arachidonoyl-CoA followed by oleoyl-CoA as acyl group donors. Functions in phosphatidic acid biosynthesis. May regulate the cellular storage of triacylglycerol through activation of the phospholipase PNPLA2. Involved in keratinocyte differentiation. Regulates lipid droplet fusion.
Target Involvement

Chanarin-Dorfman syndrome (CDS)
Target Subcellular Location

Cytoplasm. Lipid droplet. Cytoplasm, cytosol.
Target Protein Families

Peptidase S33 family, ABHD4/ABHD5 subfamily
Target Tissue Specificity

Widely expressed in various tissues, including lymphocytes, liver, skeletal muscle and brain. Expressed by upper epidermal layers and dermal fibroblasts in skin, hepatocytes and neurons (at protein level).
Target Research Area

Cancer
Target Synonyms

1-acylglycerol-3-phosphate O-acyltransferase ABHD5; ABHD5; ABHD5_HUMAN; Abhydrolase domain containing 5; Abhydrolase domain containing protein 5; Abhydrolase domain-containing protein 5; CDS; CGI 58; CGI58; CGI58 protein; IECN2; Lipid droplet-binding protein CGI-58; MGC8731; NCIE2
Target Background

The protein encoded by this gene belongs to a large family of proteins defined by an alpha/beta hydrolase fold, and contains three sequence motifs that correspond to a catalytic triad found in the esterase/lipase/thioesterase subfamily. It differs from other members of this subfamily in that its putative catalytic triad contains an asparagine instead of the serine residue. Mutations in this gene have been associated with Chanarin-Dorfman syndrome, a triglyceride storage disease with impaired long-chain fatty acid oxidation.

Rabbit anti-Human ABHD5 Monoclonal Antibody

Specifications

Immunogen Information

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