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The antibody against GATA3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GATA3 (P23771) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ChIP, ChIP-seq, ELISA.
The antibody against GATA3 was raised in Rabbit using the recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GATA3 (P23771) as the immunogen. The monoclonal antibody exists as a isotype IgG, by affinity purification. This antibody has been validated on WB, IP, ChIP, ChIP-seq, ELISA.
Chromatin immunoprecipitations were performed with cross-linked chromatin from 293T cells transfected with GATA3 and GATA3. The ChIP sequencing results indicate the enrichment pattern of GATA3 in selected genomic region and representative gene loci (SH3RF3), as shown in figure.
| Cat.No | ADA-16930A | Clonality | Monoclonal |
|---|---|---|---|
| Host Species | Rabbit | Target Name | GATA3 |
| Target Synonyms | HDR; HDRS; GATA3 | Form | Liquid |
| Species Reactivity | Human, Mouse | Isotype | IgG |
| Storage Buffer | 50% Glycerol, 0.05% BSA, PBS with 0.02% sodium azide, pH7.3. | Purification Method | Affinity purification |
| Positive Samples | MCF7, SH-SY5Y | Application | ELISA, WB, ChIP, ChIP-seq, IP |
| Immunogen Description | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GATA3 (P23771). | Target Species | Human |
|---|---|---|---|
| Immunogen Sequence | MEVTADQPRWVSHHHPAVLNGQHPDTHHPGLSHSYMDAAQYPLPEEVDVLFNIDGQGNHVPPYYGNSVRATVQRYPPTHHGSQVCRPPLLHGSLPWLDGGKALGSHHTASPWNLSPFSKTSIHHGSPGPLSVYPPASSSSLSGGHASPHLFTFPPTPPKDVSPDPSLSTPGSAGSARQDEKECLKYQVPLPDSMKLESSH | Uniprot ID | P23771 |
Uniprot Id
P23771
Target Species
Human
Target Name
GATA3
Target Full Name
Trans-acting T-cell-specific transcription factor GATA-3
Target Function
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. Positively regulates ASB2 expression.
Target Involvement
Hypoparathyroidism, sensorineural deafness, and renal disease (HDR)
Target Subcellular Location
Nucleus.
Target Tissue Specificity
T-cells and endothelial cells.
Target Synonyms
GATA 3; GATA binding factor 3; GATA binding protein 3; GATA-binding factor 3; Gata3; GATA3_HUMAN; HDR; HDRS; MGC2346; MGC5199; MGC5445; Trans acting T cell specific transcription factor GATA 3; Trans-acting T-cell-specific transcription factor GATA-3
Target Background
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia.
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