Recombinant Human Protein cereblon (CRBN)

Cat.No	ACP00412	Target Name	CRBN
Form	Liquid or Lyophilized powder	Expression System	Mammalian cell
Expression Range	1-442aa	Mol Weight	53.0 kDa
Protein Length	Full length	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP00412

Target Name

CRBN

Form

Liquid or Lyophilized powder

Expression System

Mammalian cell

Expression Range

1-442aa

Mol Weight

53.0 kDa

Protein Length

Full length

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96SW2

Background Information

Uniprot Id

Q96SW2
Target Species

Human
Target Name

CRBN
Target Full Name

Protein cereblon
Target Function

Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2 (Probable). Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. Maintains presynaptic glutamate release and consequently cognitive functions, such as memory and learning, by negatively regulating large-conductance calcium-activated potassium (BK) channels in excitatory neurons. Likely to function by regulating the assembly and neuronal surface expression of BK channels via its interaction with KCNT1. May also be involved in regulating anxiety-like behaviors via a BK channel-independent mechanism.
Target Involvement

Mental retardation, autosomal recessive 2A (MRT2A)
Target Subcellular Location

Cytoplasm. Nucleus. Membrane; Peripheral membrane protein.
Target Protein Families

CRBN family
Target Tissue Specificity

Widely expressed. Highly expressed in brain.
Target Research Area

Neuroscience
Target Synonyms

CRBN; AD-006; Protein cereblon
Target Background

This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.

Recombinant Human Protein cereblon (CRBN)

Specifications

Immunogen Information

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