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| Cat.No | ACP00712 | Target Name | AXIN2 |
|---|---|---|---|
| Target Synonyms | Axin-like protein;Axil;Axis inhibition protein 2;Conductin | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 745-843aa |
| Mol Weight | 18.4 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q9Y2T1 |
|---|
Uniprot Id
Q9Y2T1
Target Species
Human
Target Name
AXIN2
Target Full Name
Axin-2
Target Function
Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B.
Target Involvement
Colorectal cancer (CRC); Oligodontia-colorectal cancer syndrome (ODCRCS)
Target Subcellular Location
Cytoplasm.
Target Tissue Specificity
Expressed in brain and lymphoblast.
Target Research Area
Cancer
Target Synonyms
Axil; Axin like protein; Axin-2; Axin-like protein; Axin2; AXIN2_HUMAN; Axis inhibition protein 2; Conductin; DKFZp781B0869; MGC10366; MGC126582
Target Background
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
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