Recombinant Human Anoctamin-1 (ANO1), Truncated

Cat.No	ACP01019	Target Name	ANO1
Form	Liquid or Lyophilized powder	Expression System	E.coli
Expression Range	806-892aa	Mol Weight	17.6 kDa
Protein Length	Partial	Purity	Greater than 90% as determined by SDS-PAGE.
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP01019

Target Name

ANO1

Form

Liquid or Lyophilized powder

Expression System

E.coli

Expression Range

806-892aa

Mol Weight

17.6 kDa

Protein Length

Partial

Purity

Greater than 90% as determined by SDS-PAGE.

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q5XXA6

Background Information

Uniprot Id

Q5XXA6
Target Species

Human
Target Name

ANO1
Target Full Name

Anoctamin-1
Target Function

Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Cytoplasm.
Target Protein Families

Anoctamin family
Target Tissue Specificity

Broadly expressed with higher levels in liver, skeletal muscle and gastrointestinal muscles.
Target Research Area

Tags & Cell Markers
Target Synonyms

ANO 1; ANO1; ANO1_HUMAN; Anoctamin 1; Anoctamin 1 calcium activated chloride channel; Anoctamin-1; Anoctamin1; Ca2+ activated Cl- channel; Calcium Activated Chloride Channel; Discovered on gastrointestinal stromal tumors protein 1; DOG 1; DOG1; FLJ10261; Membrane protein; Oral cancer overexpressed 2; Oral cancer overexpressed protein 2; ORAOV 2; ORAOV2; TAOS 2; TAOS2; TMEM 16A; TMEM16A; Transmembrane protein 16A (eight membrane spanning domains); Transmembrane protein 16A; Tumor amplified and overexpressed sequence 2; Tumor-amplified and overexpressed sequence 2
Target Background

Enables calcium activated cation channel activity; intracellular calcium activated chloride channel activity; and iodide transmembrane transporter activity. Involved in cation transport; inorganic anion transport; and positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in apical plasma membrane and nucleoplasm.

Recombinant Human Anoctamin-1 (ANO1), Truncated

Specifications

Immunogen Information

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