Recombinant Human Beta-2 adrenergic receptor (ADRB2), Truncated

Uniprot Id

P07550

Target Species

Human

Target Name

ADRB2

Target Full Name

Beta-2 adrenergic receptor

Target Function

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Early endosome. Golgi apparatus.

Target Protein Families

G-protein coupled receptor 1 family, Adrenergic receptor subfamily, ADRB2 sub-subfamily

Target Research Area

Cardiovascular

Target Synonyms

ADRB2; ADRB2R; B2AR; Beta-2 adrenergic receptor; Beta-2 adrenoreceptor; Beta-2 adrenoceptor

Target Background

This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease.