Recombinant Human Chorionic somatomammotropin hormone 2 (CSH2)

The region for expressing recombinant Human CSH2 contains amino acids 27-217. The theoretical molecular weight of the CSH2 protein is 53.8 kDa. Expression of this CSH2 protein is conducted in e.coli. The CSH2 gene fragment has been modified by fusing the N-terminal 6xHis-GST tag, providing convenience in detecting and purifying the recombinant CSH2 protein during the following stages.The human chorionic somatomammotropin hormone 2 (CSH2) is a glycoprotein hormone produced by the syncytiotrophoblast cells of the placenta during pregnancy. CSH2 shares structural similarities with growth hormone and prolactin. Its primary function is to regulate maternal metabolism and promote fetal growth by modulating insulin sensitivity and glucose utilization. CSH2 also plays a role in mammary gland development in preparation for lactation. During pregnancy, its levels rise steadily, peaking in the third trimester. The hormone contributes to maintaining a nutrient-rich environment for the developing fetus. Studying CSH2 provides insights into the intricate hormonal regulation crucial for successful pregnancy outcomes.